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The most typical remedy-emergent AEs (all grades) have been anemia (60.three%), decreased neutrophil and white blood cell counts (41.2% and 32.7%, respectively), neutropenia (35.7%), thrombocytopenia (21.6%), fatigue (19.6%), higher respiratory tract an infection (19.6%), and pneumonia (18.6%).
Conclusions: The Okay-GEM showed KRd is worth-effective, with an ICER of $107,520 per QALY gained in opposition to Rd for the treatment of patients with RMM (1-three prior therapies) at a willingness-to-pay threshold of $150,000. Girls should not turn into pregnant for four weeks before therapy, throughout remedy and for four weeks after remedy is stopped.
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